CREW02
Study Overview
This research project studies the relationship between childhood asthma and early-life environmental factors that may cause the disease. Previous birth cohort studies have found early-life environmental factors such as allergens, pollutants, viruses and bacteria have all contributed to the development of asthma. We are doing this research because there continues to be a strong need to understand the root causes of asthma.
There are 12 individual U.S. birth cohort sites that make up the CREW consortium. The CREW consortium will include data from a large number of adults and children who were previously or are currently enrolled in a birth cohort study about asthma. It will study different types of asthma that developed during childhood and other early-life environmental factors that may have contributed to the development of asthma.
Why Participate?
- To help scientists better understand the root causes of asthma.
Who can participate in the study?
- If you were enrolled in a previous CREW study cohort, you are eligible to participate. Please contact your local participating site (see the Sites tab) to confirm eligibility and participate.
What to Expect
Procedures
Click each bullet to learn more about these procedures.
Demographic information
name, address, former address, birthdate, email address, phone number, etc
Physical Exam
Physical examinations will include height and weight, hip and waist circumference, heart rate, and blood pressure.
Questionnaire administration
We will ask you questions about your past and present medical history, asthma and allergy symptoms, and smoke exposure.
Blood
We will draw up to 4 tablespoons of blood from you to look at the numbers and types of cells in your blood.
Urine Collection
Urine will be collected during your study visit to look at signs of inflammation that might be related to asthma.
Nasal Lavage
A nasal lavage will be collected during your visit to look at numbers and types of cells in your nose and to look at viruses in your nose. First, you will wet your nose with a salt solution (such as Deep Sea Nasal Spray) and blow your nose into a baggie. Then, while sitting, 1/2 a cup of salt water will be put into each of your nostrils, one side at a time. The fluid is recovered from the other nostril in a collection cup.
Nasal Brush
If you agree, you will be asked to provide a sample of cells from the inside of your nose to examine the kinds of protein and types of cells in your nose. You will be first asked to blow your nose. Nasal cells will be collected by putting a small lighted scope in one side of the nose. A tiny brush (the size of a Q tip) is put in through the scope and moved in and out for 4 seconds. The scope and brush are then removed at the same time from the nose.
Stool
You will be asked to provide a stool sample to examine the bacterial and fungal content of your stool. You can either collect the stool at home using the provided collection kit and instructions, or at the clinic visit using the provided collection kit.
Skin prick testing
Skin prick allergy testing is a common test to determine what allergies you may have. the skin on the underside of your forearm will be lightly scratched where the drops of extract are placed. After 10-15 minutes we will look for redness and/or swelling (like a mosquito bite) where the tests were done.
Spirometry with Reversibility
Spirometry is a test used to see how well your lungs are working. Reversibility will tell us if your lungs get better after using albuterol (or Xopenex if this is the rescue inhaler you currently use).
Exhaled Nitric Oxide (eNo)
Nitric oxide is a gas that is released from inflammatory cells in the lung. You will gently blow air out into a machine for a 10 second period of time.
**Some of the above procedures may not be performed due COVID-19 restrictions
Compensation
- You will be compensated for your time and participation in the study.
Participating Sites and Cohorts
- Henry Ford Health System, Detroit, MI
- WHEALS
- CAS
- MAAP
- University of Wisconsin-Madison, Madison, WI
- COAST
- MCRI, Marshfield, WI
- WISC
- Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
- CCAAPS
- Columbia University, New York, NY
- CCCEH
- URECA
- Harvard University, Boston, MA
- EHAAS
- Vanderbilt University, Nashville, TN
- INSPIRE
- Boston University, Boston, MA
- URECA
- Johns Hopkins University, Baltimore, MD
- URECA
- Washington University, St. Louis, MO
- URECA